EXPLORING CREATININE METABOLISM IN MITOCHONDRIAL PLASMA OF DYING CELLS IN STROKE PATIENTS: IMPLICATIONS FOR CELLULAR SURVIVAL AND THERAPEUTIC STRATEGIES
Keywords:
Keywords: Stroke, Creatinine Metabolism, Mitochondrial Dysfunction, Therapeutic Strategies, Ischemia, Cellular Survival.Abstract
Abstract: Stroke, a global health concern, poses a significant challenge to researchers and healthcare professionals alike. This article delves into the intricate realm of creatinine metabolism within the mitochondrial plasma of cells in stroke patients, shedding light on its role in the complex cascade of events during ischemic insult. The exploration of creatinine’s involvement in mitochondrial dysfunction not only expands our understanding of stroke pathophysiology but also presents potential avenues for targeted therapeutic interventions. This research contributes to the International Journal of Scientific Research in Biological Science by offering insights into the cellular dynamics of stroke and proposing novel perspectives for future investigations.
References
Dorn G. W., II, Kitsis R. N. (2015). The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ. Res. 116 167–182. 10.1161/circresaha.116.303554
Cardoso A. R., Queliconi B. B., Kowaltowski A. J. (2010). Mitochondrial ion transport pathways: role in metabolic diseases. Biochim. Biophys. Acta 1797 832–838. 10.1016/j.bbabio.2009.12.017 [PubMed] [CrossRef] [Google Scholar] [Ref list]
Chan D. C. (2020). Mitochondrial dynamics and its involvement in disease. Annu. Rev. Pathol. 15 235–259. 10.1146/annurev-pathmechdis-012419-032711: http://www.ctan.org/tex-archive/macros/latex/contrib/supported/IEEEtran/
Cohen M. M., Tareste D. (2018). Recent insights into the structure and function of Mitofusins in mitochondrial fusion. F1000Research 7:1983. 10.12688/f1000research.16629.
Pise, P. J., 1982, Laterally loaded piles in a two-layer mitochondrial system., J. Geotech. Engrg. Div., 108(9), 1177–1181.
Poulos, H. G., 1971, Behavior of laterally loaded piles-I: Single piles., J. Soil Mech. and Found. Div., 97(5), 711–731.
Pagliuso A., Cossart P., Stavru F. (2018). The ever-growing complexity of the mitochondrial fission machinery. Cell. Mol. Life Sci. 75 355–374. 10.1007/s00018-017-2603-0
Abrisch R. G., Gumbin S. C., Wisniewski B. T., Lackner L. L., Voeltz G. K. (2020). Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology. J. Cell Biol. 219:e201911122. 10.1083/jcb.201911122.