Ta'lim innovatsiyasi va integratsiyasi

DRUG ALLERGIC REACTIONS: CURRENT VIEWS (REVIEW)

BAKHROMOVA BARNO ZOKIROVNA

ALIBAYEVA YULDUZ RAHMANOVNA

MUMINBOYEV DIYORBEK JASURBEK OGLU

Ключевые слова: Key words: drug allergy; diagnosing drug allergy; drug hypersensitivity reactions.

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Аннотация

More than 7% of population suffer from drug allergy. Cases of heavy life-
threatening allergic reactions are well known. In this review current considerations of
mechanisms of drug immune hypersensitivity development are presented, the main
clinical forms and methods of diagnosing drug allergy are described. Drug allergy is
diagnosed with specific in vivo tests (skin prick test, intradermal test, patch test,
provocation tests) and in vitro tests (determination of specific IgE to medications, test
for basophil activation, reactions of leucocyte blast transformation, quantitative
determination of cytokines and other proteins, e.g. granzyme and tryptase in peripheral
blood). However, not all of these methods are available in real clinical practice, the list
of commercial kits for diagnosis of drug allergy is limited. Therefore, it is especially
important in patient management to rely on history-taking and general clinical
examination data, to consider the available information on association of drug allergy
and infections caused by viruses of herpes-group, especially in children population, on
hereditary predisposition to some kinds of drug allergy.

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Библиографические ссылки

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