Ta'lim innovatsiyasi va integratsiyasi

STRUCTURAL AND FUNCTIONAL FEATURES OF THE LEFT VENTRICLE IN PATIENTS WITH HEART FAILUREIN ISCHEMIC HEART DISEASE AND THYROTOXICOSIS

Khusainova Munira Alisherovna

Ibodulloyeva Marjona Habibulloyevna

Rabbimova Fariza Voxidovna

Ключевые слова: Keywords: left ventricle, thyrotoxicosis, chronic heart failure, coronary heart disease

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Аннотация

ABSTRACT
Goal. To determine the structural and functional features of the left ventricle in
patients with chronic heart failure with coronary heart disease and thyrotoxicosis.
Materials and methods. 85 patients aged 58.3±5.6 years were divided into 3 groups:
the main group consisted of 25 patients with coronary heart disease (CHD), chronic
heart failure (CHF) of functional classes II−III (FC) and thyrotoxicosis, the average
age was 59.23±3.81; the 1st comparison group consisted of 30 patients with CHD, HSN
FC II-III, without thyroid pathology, average age – 57.6±2.73; comparison group 2 –
30 patients with thyrotoxicosis without concomitant cardiovascular diseases (CVD),
average age – 45.4±3.51. The structure and function of the thyroid gland were studied
in all patients, and an echocardiographic (EchoCG) study was performed to assess the
structural and functional parameters of the left ventricle (LV). Results. Pathological
LV remodeling in patients of the main group is represented by two types: concentric
LV hypertrophy (LVH) and eccentric LV hypertrophy (LVH), and LVH was more
common than in patients without thyroid pathology with CHF on the background of
coronary heart disease (84.0%, p=0.01). The contractility of the LV myocardium in
patients of both groups with CHF was reduced, the values of the ejection fraction
corresponded to the intermediate type of HF, there was no significant difference
between the indicators (p=0.1). In the main The group of patients showed a
significantly more pronounced decrease in the ratio of the blood flow rate of early LV
diastolic filling and the maximum rate of atrial systole (E/A) – 0.63 and an increase in
isovolumetric relaxation time (IVRT) – 84.69 ms compared with the indicators of
patients with ischemic heart failure without thyroid pathology (p=0.021; p=0.034).
Conclusion. For patients with CHF on the background of coronary heart disease and
thyrotoxicosis, the predominance of remodeling is characteristic LV by type of LVL
(84.0% of cases), moderate decrease in LV contractility and more pronounced diastolic dysfunction, which determines the structural and functional features of LV in patients
with CHF in the presence of this comorbidity. 

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Библиографические ссылки

LITERATURE

Khusainova, M. A., Eshmamatova, F. B., Ismoilova, K. T., & Mamadiyorova, M. M. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS AS A CRITERION OF CARDIOVASCULAR RISK. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 331-339.

Khusainova, M. A. (2023). CYSTATIN C IS AN EARLY MARKER OF DECREASED KIDNEY FUNCTION. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 485-490.

Khusainova, M. A., Vakhidov, J. J., Khayitov, S. M., & Mamadiyorova, M. M. (2023). Cardiac arrhythmias in patients with rheumatoid arthritis. Science and Education, 4(2), 130-137.

Khusainova, M. A., Ergashova, M. M., Eshmamatova, F. B., & Khayitov, S. M. (2023). Features of quality of life indicators in patients with pneumonia. Science and Education, 4(2), 138-144.

Khusainova, M. A. (2023). Comorbidity thyrotoxicosis with coronary heart disease. Science and Education, 4(5), 205-213.

Uzokov, J. B., Khusainova, M. A., Eshmamatova, F. B., & Mamadiyorova, M. M. (2023). Correction of violations rheology of blood in ischemic heart disease. Science and Education, 4(2), 153-159.

Khusainova, M. A., Gafforov, X. X., Eshmamatova, F. B., & Khayitov, S. M. (2023). Assessment of the quality of life in patients with exogenous allergic alveolitis. Science and Education, 4(2), 145-152.

Khusainova, M. A., Khaydarov, S. N., Makhmudova, K. D., & Ortikova, S. X. (2023). Features of prevention of chronic kidney diseases and chronic heart failure. Science and Education, 4(5), 242-250.

Khaydarov, S. N., Khusainova, M. A., Uzokov, J. B., & Makhmudova, K. D. (2023). Heart failure and the risk of hypoglycemia. Science and Education, 4(5), 222-231.

Khusainova, M. A., Khaydarov, S. N., Makhmudova, K. D., & Nayimov, A. S. (2023). Prevalence of bronchiolitis in patients with Rheumatoid arthritis. Science and Education, 4(5), 232-241.

Yarmatov, S., Khusainova, M., & Djabbarova, N. (2023). STUDY OF QUALITY OF LIFE INDICATORS IN PATIENTS WITH CORONARY HEART DISEASE USING THE SF-36 QUESTIONNAIRE. Бюллетень студентов нового Узбекистана, 1(7), 58-64.

Alisherovna, K. M., Totlibayevich, Y. S., Xudoyberdiyevich, G. X., & Jamshedovna, K. D. (2022). CLINICAL FEATURES OF HEART FAILURE IN PATIENTS WITH ISCHEMIC HEART DISEASE AND THYROTOXICOSIS. Spectrum Journal of Innovation, Reforms and Development, 7, 108-115.

Alisherovna, K. M., & Xudoyberdiyevich, G. X. Features of Heart Damage in Patients with Viral Cirrhosis of the Liver. International Journal of Innovations in Engineering Research and Technology, 8(04), 53-57.

Alisherovna, K. M., Toshtemirovna, E. M. M., Duskobilovich, B. S., & Umirxanovna, K. G. (2022). DYSFUNCTION LEFT VENTRICULAR IN BRONCHIAL ASTHMA. Spectrum Journal of Innovation, Reforms and Development, 4, 216-221.

Alisherovna, K. M., Totlibayevich, Y. S., Xudoyberdiyevich, G. X., & Jamshedovna, K. D. (2022). EFFICACY OF DRUG-FREE THERAPY OF HYPERTENSION DISEASES IN THE EARLY STAGE OF THE DISEASE. Spectrum Journal of Innovation, Reforms and Development, 7, 82-88.

Yarmukhamedova, S. K., Alisherovna, K. M., Tashtemirovna, E. M. M., & Nizamitdinovich, K. S. (2023). The Effectiveness of Trimetazidine in Arrhythmias. Miasto Przyszłości, 33, 215-221.

Alisherovna, K. M., Toshtemirovna, E. M. M., & Oybekovna, E. E. (2022). Quality of life of patients with cirrhosis of the liver. Spectrum Journal of Innovation, Reforms and Development, 4, 197-202.

Alisherovna, K. M., Kairatovna, R. A., Umirovna, I. S., & Oybekovich, T. M. (2023). CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ANEMIA. Spectrum Journal of Innovation, Reforms and Development, 21, 140-147.

Khabibovna, Y. S., & Alisherovna, K. M. (2024). STRESS TESTING IN PATIENTS WITH CORONARY HEART DISEASE. Journal of new century innovations, 45(3), 28-33.

Alisherovna, K. M., Kulmuxammatovich, Y. U., Boymamatovna, E. F., & Shokirovich, S. A. (2023). THE STATE OF NEUROPEPTIDE-CYTOKINE STATUS IN ISCHEMIC HEART DISEASE. Spectrum Journal of Innovation, Reforms and Development, 11, 42-50.

Alisherovna, K. M., Nizamitdinovich, K. S., Rustamovich, T. D., & Haqnazarovich, K. S. (2022). Mental Status and Quality of Life in Patients With Sinus Node Weakness Syndrome and Chronic Coronary Heart Failure of Ischemic Etiology. Texas Journal of Medical Science, 15, 78-82.

Alisherovna, K. M., Erkinovna, K. Z., Djamshedovna, K. D., & Nizamitdinovich, K. S. (2023). QUALITY OF LIFE PATIENTS WITH OSTEOARTHRITIS. Journal of new century innovations, 36(1), 164-175.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., Tashtemirovna, E. M. M., Abdukadirovna, A. S., & Jasurovna, J. S. (2023). DEPRESSION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH ATRIAL FIBRILLATION. Journal of new century innovations, 39(1), 185-189.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Djamshedovna, K. D., & Alisherovna, K. M. (2024). CHANGES IN SOME SYSTEM INDICATORS IN PREGNANT WOMEN WITH GESTOSIS. Spectrum Journal of Innovation, Reforms and Development, 25, 111-115.

Alisherovna, K. M., Djamshedovna, K. D., Totlibayevich, Y. S., & Boymamatovna, E. F. (2022). The Effectiveness of the Original Drug Trimetazidine MV in Patients with Stable Ischemic Heart Disease and Persistent Angina Attacks Against the Background of the Use of Trimetazidine Generics. Miasto Przyszłości, 30, 235-238.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Nizamitdinovich, K. S., & Abdukadirovna, A. S. (2023). ANTITHROMBOTIC THERAPY IN CARDIOLOGICAL PATIENTS. Journal of new century innovations, 39(1), 169-171.

Alisherovna, K. M., & Djamshedovna, K. D. (2024). AFTER COVID-19 QUALITY OF LIFE. Spectrum Journal of Innovation, Reforms and Development, 25, 103-110.

Alisherovna, K. M., Erkinovna, K. Z., Davranovna, M. K., & Pulotovna, Z. D. (2022). Positive Effect of Sorbitol in Patients with Chronic Renal Insufficiency. Miasto Przyszłości, 30, 214-217.

Alisherovna, K. M., Akmalovna, K. N., & Mamasoliyevna, D. N. (2022). Kidney dysfunction in chronic heart failure. Texas Journal of Medical Science, 13, 104-109.

Nizamitdinovich, K. S., Khabibovna, Y. S., Alisherovna, K. M., & Tashtemirovna, E. M. M. (2023). Spinal Injury for Rheumatoid Arthritis. Miasto Przyszłości, 40, 426-432.

Baxtiyorovich, U. J., Alisherovna, K. M., & Mamasoliyevna, D. N. (2023). Features of cognitive impairment in patients with chronic kidney disease at predialysis stages. World Bulletin of Public Health, 22, 49-54.

Khabibovna, Y. S., Alisherovna, K. M., Erkinovna, K. Z., & Djamshedovna, K. D. (2023). Gender Characteristics of the Course of Rheumatoid Arthritis. Miasto Przyszłości, 40, 438-442.

Alisherovna, K. M., Totlibayevich, Y. S., Xudoyberdiyevich, G. X., & Jamshedovna, K. D. (2022). PSYCHOSOMATIC FEATURES AND THE LEVEL OF DEPRESSION WITH CHRONIC HEART FAILURE IN PATIENTS WITH ARTERIAL HYPERTENSION AND CORONARY HEART DISEASE. Spectrum Journal of Innovation, Reforms and Development, 7, 89-95.

Alisherovna, K. M., Akramovna, I. K., & Yorkinovna, E. N. (2024). CLINICAL AND MORPHOLOGICAL CRITERIA OF COLITIS IN PATIENTS WITH CHRONIC ISCHEMIC DISEASE OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 18(6), 6-13.

Alisherovna, K. M., Akramovna, I. K., & Kairatovna, R. A. (2024). THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH OSTEOARTHRITIS WITH CARDIOVASCULAR DISORDERS IN METABOLIC SYNDROME. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 223-230.

Akramovna, I. K., & Alisherovna, K. M. (2024). CAUSES OF ARRHYTHMIA DURING PREGNANCY. Journal of new century innovations, 45(3), 34-41.

Alisherovna, K. M., Akramovna, I. K., & Baxtiyorovna, O. K. (2024). THE COURSE OF CHRONIC ISCHEMIC PANCREATITIS IN PATIENTS WITH CORONARY HEART DISEASE. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 231-239.

Mamasoliyevna, D. N., Alisherovna, K. M., & Totlibayevich, Y. S. (2023). Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: the Facets of Conjugacy. Miasto Przyszłości, 35, 166-173.

Mamasoliyevna, D. N., Akmalovna, K. N., & Alisherovna, K. M. (2022). Quality of Life Depending on Gender. The Peerian Journal, 11, 71-77.