Ta'lim innovatsiyasi va integratsiyasi

PHARMACOEPIDEMIOLOGY AND BIOINFORMATICS: EVOLUTION AND INTEGRATION OF ANALYTICAL WAYS ON PRECISION THERAPEUTICS ON CARDIOVASCULAR RISK

BAKHROMOVA BARNO ZOKIROVNA

KURBONOV KHUSAN USMON OGLU

MUMINBOYEV DIYORBEK JASURBEK OGLU

DUSMUROTOV BAHODIR SHUXRAT OGLU

Keywords: Keywords: Cardiovascular drugs, database, computational biology, medical informatics, analytical epidemiology, pharmacogenomics

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Abstract

The pharmacological intervention is positioned as a common element in the
process of approaching patients at different levels of care, with the aim of limiting the
natural evolution of various pathological conditions, generating symptomatic relief,
preventing and in some circumstances, diagnosing. The use of therapeutic molecules
within the framework of clinical decisions requires the conjunction and analysis of
elements such as pharmacological, regulatory, epidemiological knowledge and
individual characterization of the patient. This complex and multivariate scenario
implies an important effort of the health professional, who will also find himself with
a systematic element in front of the exposure to drugs: the adverse drug reactions,
unwanted and within the therapeutic spectrum. To support the professional in the area
of health sciences, bioinformatics and biostatistical information analysis processes
arise, techniques that together with the advance in omics sciences, allow to describe,
generate inference, explain, predict and apply knowledge of the science of data, at the
bedside of the patient. The incorporation of bioinformatics and pharmacological
analysis in complex levels of health care, with special reference to cardiovascular
drugs, would allow to anticipate problems derived from interactions, indications, use,
compliance, and clinical impact.

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