АЛЮМИНИЙ МОДДАСИНИНГ ОРГАНИЗМГА ВА БОШ МИЯГА ТАЬСИРИ, УНИНГ САЛБИЙ ОҚИБАТЛАРИ.

Зарипова Ойсара Олимжон қизи.

Keywords: Калит сўзлар:Алюминий бирикмалари, бош мия, Алцгеймер касаллиги, Аутизм.


Abstract


Аннотация: Алюминий ер юзида энг кенг тарқалган элементлардан бири
бўлиб, кислород ва кремнийдан сўнг учинчи ўринда туради. Табиатда алюминий
бирикмалари хилма хил, ҳар хил кўринишда учрайди. Алюминий бирикмалари
280 дан ортиқ минераллар таркибига киради ва инсон фаолиятининг турли
жабҳаларида фаол қўлланилади. Алюминий бирикмалари кенг қўлланилсада
унинг салбий оқибатлари хозирги тиббиётнинг муҳим ва ҳал қилиниши зарур
бўлган муаммоларидан бири бўлиб қолмоқда.Айниқса унинг мия билан боғлиқ
асоратлари кўплаб муҳокамаларга сабаб бўлмоқда. Алцгеймер касаллиги,
аутизм, паркинсонизм, кучайиб борувчи склероз ва шунга ўхшаш мия билан
боғлиқ чуқур ўзгаришлар айнан алюминий ва унинг бирикмалари таъсирида
юзага чиқиши ҳақида кўплаб мунозаралар ҳалигача давом этмоқда. (1)
Алюминий ичимлик суви, нафас орқали ва озиқ-овқат маҳсулотлари
орқали кўп миқдорда киришига қарамасдан шиллиқ қаватлардан кам миқдорда
реабсорбция бўлади.


References

Фойдаланилган адабиётлар:

Bryli´nski, Ł.; Kostelecka, K.;Woli´nski, F.; Duda, P.; Góra, J.;Granat, M.; Flieger,

J.; Teresi´nski, G.;Buszewicz, G.; Sitarz, R.; et al.Aluminium in

theHumanBrain:Routes of Penetration, Toxicity, andResulting Complications.

Int.J. Mol.Sci. 2023, 24, 7228. https://doi.org/

Capriello, T.; Di Meglio, G.; De Maio, A.; Scudiero, R.; Bianchi, A.R.; Trifuoggi,

M.; Toscanesi, M.; Giarra, A.; Ferrandino, I.Aluminium Exposure Leads to

Neurodegeneration and Alters the Expression of Marker Genes Involved to

Parkinsonism inZebrafish Brain. Chemosphere 2022, 307, 135752. [CrossRef]

[PubMed

Exley, C.; House, E.R. Aluminium in the Human Brain. Mon. Chem. 2011, 142,

–363. [CrossRef]

Igbokwe, I.O.; Igwenagu, E.; Igbokwe, N.A. Aluminium Toxicosis: A Review of

Toxic Actions and Effects. Interdiscip. Toxicol.

2019, 12, 45–70. [CrossRef]

Inan-Eroglu, E.; Ayaz, A. Is Aluminum Exposure a Risk Factor for Neurological

Disorders? J. Res. Med. Sci. 2018, 23, 51.

Aluminium in Biological Environments: A Computational Approach / Jon I Mujika,

Elixabete Rezabal, Jose M Mercero [et al.] // Computational and structural

biotechnology journal. – 2014. – Vol. 9, issue 15. – P. 1–13.

Statement of EFSA. On the Evaluation of a new study related to the bioavailability

of aluminium in food // EFSA Journal. – 2011. – Vol. 9, №5. – P. 2157–2173

Safety of aluminium from dietary intake. Scientific Opinion of the Panel on Food

Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) / F.

Aguilar, H. Autrup, S. Barlow [et al.] // The EFSA Journal. – 2008. – Vol. 754. –

P. 1–34.

Aluminium from all sources, including food additives and contaminants

(addendum). First draft / D.J. Benford, N. Thatcher, D. Mason [et al.] // Safety

evaluation of certain food additives and contaminants. WHO Food

Aluminium-containing food additives // Evaluation of certain food additives and

contaminants. WHO Technical Report Series 966. – 2011. – P. 7–14.additives. –

– Ser. 58. – P. 119–209.

Statement of EFSA. On the Evaluation of a new study related to the bioavailability

of aluminium in food // EFSA Journal. – 2011. – Vol. 9, №5. – P. 2157–2173.

Aluminium-containing food additives (addendum) // Safety evaluation of certain

food additives and contaminants. Prepared by the Seventy-fourth meeting of the

Joint FAO / WHO Expert Committee on Food Additives (JECFA). WHO food

additives. – 2012. – Ser. 65. – P. 3–87

Aluminum and silica in drinking water and the risk of Alzheimer's disease or

cognitive decline: findings from 15-year follow-up of the PAQUID cohort /

VirginieRondeau, Hélène Jacqmin-Gadda, Daniel Commenges [et al.] // Am. J.

Epidemiol. – 2009. – Vol. 169 (4). – P. 489–496.

Relation between aluminum concentrations in drinking water and Alzheimer's

disease: an 8-year followup study / Virginie Rondeau, Daniel Commenges, Hélène

Jacqmin-Gadda [et al.] // Am. J. Epidemiol. – 2000. – Vol. 152 (1). – P. 59–66.